First it was the records shops, then the bookstores, the electronic retailers are already being hit. (BBY today!)
Pharmacys, shore stores & perfume shops are slowing seeing their customers move to the internet.
Basically any item that can be easily identified i.e. any brand name will always be found cheaper on the internet. Some of the french perfume houses are trying to stop this through the French courts, but alas the internet will always prevail.
So the retail space will be full of clothes shops and restaurants in the foreseeable future.
I am just waiting for my FL (Foot Locker) sales to drop.